Hilarious video here.
(And yes, I so totally am trying this if I ever get the chance. :-D )
Incidentally, when I first saw the caption to this, as a chemical engineer I immediately thought it was a mocked-up video of Jay Leno inhaling something and then having his head (and studio, and most of Upper Manhattan) vanish in a huge matter/antimatter annihilation event. Instead, it's live (and thoroughly entertaining) footage of Leno inhaling something that's probably sulfur hexafluoride (SF6).
<shrug> There are worse things to be mistaken about. :-)